Wednesday, April 7

1:30 pm - 4:30 pm

Short Courses - Jin Jiang Hotel

LC-MS/MS Applications in Support of ADME and PK/TK Studies
Lucy Xu, Novartis, Shanghai, China

Absolute Quantification of Peptides and Proteins: From Sample Preparation and Chromatography to ESI-MS/MS
Nalini Sadagopan, Agilent Technologies
Gary Valaskovic, New Objective

Recent Developments in Separation Sciences for Pharmaceutical Analysis Roman Szucs, Pfizer
Gang Xue, Pfizer

5:30 pm - 7:30 pm

Pre-Event Dinner Reception and Registration - Jin Jiang Hotel

This is AB SCIEX - A New Company, Rich in History
Gary Impey, AB SCIEX

New Advances in CYP Drug Interaction Assays Based on Small Molecule and Protein Analysis
Hua-fen Liu, AB SCIEX

Is There a Single LC/MS Platform Suitable for all Discovery DMPK Studies?
Mingshe Zhu, Bristol-Myers Squibb

Thursday, April 8

7:30 am - 8:30 am

Reigistration & Continental Breakfast

8:30 am - 8:40 am

Welcome
Mike S. Lee, Milestone Development Services

8:40 am - 9:00 am

Objectives, Format & Opening Remarks
Yining Zhao, Pfizer

9:00 am - 10:00 am

Plenary Lecture

Challenges and Opportunities of Pharmaceutical Regulatory Environment for Analytical Sciences - An Industrial Perspective
Charles Tong, Global CMC, Pfizer
George Reid, Analytical R&D, Pfizer

10:00 am - 10:30 am

Break / Roundtables

10:30 am - 11:45 am

From Data to Knowledge:
ADME Data Integration in Drug Discovery
Discussion Leader: Haojing Rong, Pfizer

When ADME Meets Potency - It's All About the Dose
Haojing Rong, Pfizer

The Use of ADME/PK Information in Lead Optimization and Drug Candidate Selection
Frank Lee, Millennium Pharmaceuticals

Strategies and Experiences in DMPK Support of Drug Discovery at China R&D Center
Jeff Zhang, Novartis Institutes for Biomedical Research Co., Ltd.

11:45 am - 12:15 pm

Break / Roundtables

12:15 pm - 1:30 pm

Complimentary Lunch / Roundtables

1:30 pm - 2:45 pm

Strategic Measurement and Utility of Biomarkers in the Drug Development Continuum
Discussion Leader: Nalini Sadagopan, Agilent Technologies

Optimizing Peptide Quantitation in Drug Discovery
Christine Miller, Agilent Technologies

Integrating Data to Generate Knowledge for Drug Discovery: A Role for PK-PD and Translational Research
Paolo Vicini, Pfizer

Use of Biomarkers in Proof of Concept Trials
Thomas Evans, Novartis

2:45 pm - 3:15 pm

Break / Roundtables

3:15 pm - 4:30 pm

Computational Tools in Support of Analytical Chemistry
Discussion Leader: Roman Szucs, Pfizer

In-Silico Tools for Method Chromatographic Method Development
Roman Szucs, Pfizer

Automated Peak Tracking in Orthogonal Chromatography
Gang Xue, Pfizer

Computational Tools in Material Sciences
Neil Feeder, Pfizer

4:30 - 5:00 pm

Break / Roundtables

5:00 pm - 6:15 pm

Future Direction for Bioanalysis
Discussion Leader: Jing-Tao Wu, Millennium Pharmaceuticals

Bioanalysis Beyond ADME: From Systemic Exposure to Active Drug at the Target
Jing-Tao Wu, Millennium Pharmaceuticals

Insights into Pharmacology Through Mass Spectrometry Based Tissue Imaging
Yan-Hui Liu, Schering-Plough Research Institute

Integrating DMPK with Biology for CNS Drug Discovery
Eric Yang, GlaxoSmithKline

6:15 pm - 8:00 pm

Keynote Dinner Lecture

Chip-Based Technology to Enable Biomarker Analysis
John Fjeldsted, Agilent Technologies

Friday, April 9

7:30 am - 8:30 am

Reigistration & Continental Breakfast

8:30 am - 9:30 am

Plenary Lecture

DMPK in Drug Discovery and Development
Li Hua, The Academy of Military Medical Sciences

9:30 am - 10:00 am

Break / Roundtables

10:00 am - 11:30 am

Leveraging Chinese Research Capabilities to Enable Pharma R & D
Discussion Leader: Todd A. Gillespie, Eli Lilly and Company

Methodology and Technology for Drug Discovery from Traditional Chinese Medicine (TCM)
Xinmiao Liang, Dalian Institute of Chemical Physics

Utilization of Synthetic & Characterization Capabilities to Enable Commercial CMC Strategy
Todd A. Gillespie, Eli Lilly and Company

Analytical Research Alliances - A Case Study of Collaboration Between Pfizer and Chinese Academic Laboratories
Jian Wang, Gang Xue, Klaus Rumpel, Yining Zhao, and Roman Szucs, Pfizer Global R & D, Pfizer Inc.; Pat Sandra, PARC, University of Ghent, Belgium; Qun Gu, Qin Li, and Guowang Xu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

11:30 am - 12:45 pm

Complimentary Lunch / Roundtables

12:45 pm - 2:00 pm

Early CMC Development in China
Discussion Leader: Brian Winger, Eli Lilly and Company

Early CMC Development in China to Enable Phase I Clinical Trials
Brian Winger, Eli Lilly and Company

CMC development strategies at WuXi - Now and Future
Youxiang Gong, Wuxi AppTec

Bridging Research and Development - Fast to PoC
Nick Zhang, Novartis

2:00 pm - 2:30 pm

Break / Roundtables

2:30 pm - 3:45 pm

Advanced Technologies in LC-MS
Discussion Leader: Tim Schlabach, Agilent Technologies

The Use of Dried Blood Spot Samples in Drug Development
Chris Evans, GlaxoSmithKline

High Throughput ADME Profiling
Angela Wong, WuXi AppTec

Nano Flow Technology and Its Application in Drug Metabolism Studies
Lucy Xu, Novartis, Shanghai, China

Will Mass Spectrometry Replace the Plate Reader? The Emerging Role of High-Throughput MS in Drug Discovery
Can Ozbal, BIOCIUS Life Sciences, Inc.

3:45 pm - 4:00 pm

Wrap Up & Adjourn
Mike S. Lee, Milestone Development Services
Yining Zhao, Pfizer

4:00 pm - 6:00 pm

Post-Event Workshops

Good Bioanalytical Science in Drug Development
Discussion Leaders: Daniel Tang, Frontage Laboratories, and Naidong Weng, Johnson & Johnson

Chiral Separations and Analysis of Pharmaceuticals
Discussion Leaders: Xiaoyi Gong, Merck Research Laboratories; Jerry Wang, Agela Technologies, and Eugene Zhao, Welch Materials

New Technologies and Novel Applications
Discussion Leaders: Masayuki Nishimura and Fan Xiang, Shimadzu; William Shi, Esensing Analytical Technology, and Jian Wang, Bristol-Myers Squibb

Download Conference Program