PARALLEL SESSIONS : Tracks 1 - 4

TRACK 1
In Vitro ADME Challenges and Advances

Chairs: Mandy Xu, Pharmaron; Zhengyin Yan, Genentech

Improving Confidence in PPB Determinations for Highly Bound Drugs
Zhengyin Yan, Genentech

Novel Hepatic Spheroid Systems for Drug Discovery and Development
Volker Lauschke, Karolinska Institutet

Preclinical Evaluation of BBB Penetration of EGFR TKIs using in vitro and in vivo Tools
Kan Chen, AstraZeneca Asia

In vitro Human-Based Experimental Systems for the Evaluation of Human Drug Properties
Albert Li, In Vitro ADMET Laboratories

TRACK 2
Small Molecule Bioanalysis

Chairs: Luke Bi, Covance; Jonathan Wang, Genentech

The Determination of Antiretroviral Triphosphate Metabolite in Human Peripheral Blood Mononuclear Cells
Deqing Xiao, Gilead

Bioanalytical Challenges in the Development of Combination Therapies
Jonathan Wang, Genenetech

LC-MS/MS Analysis of Drug in Hemolyzed Samples for Supporting BE Application: A Case Study
Minji Wei, Institute of Clinical Pharmacology, Peking University

TRACK 3
Omics and Biomarker Challenges

Chairs: Yu Tian, Abbvie; Kelly Dong, UP Pharma

A Simple and High-Coverage Quantitative Metabolomics Platform Based on Chemical Isotope Labeling LC-MS
Liang Li, University of Alberta

Highly Sensitive Targeted Quantification of Proteins, Isoforms, and Modifications in Biofluids or Specific Cellular Pathways
Weijun Qian, Pacific Northwest National Laboratory

Critical Factors in Exploratory Biomarker Outsourcing in Clinical Studies
Helen Yu, Novartis

TRACK 4
Pharmaceutical Development:
From Discovery to First-in-Human

Chair: Qun Lu, Celgene

FIH Clinical Supply in China: Challenges and Changes
Larry Fang, Sinotherapeutics

Development, Characterization and Physical Stability of Amorphous Pharmaceutical Solids
Cai Ting, Chinese Pharmaceutical University

Roundtable Discussion

PARALLEL SESSIONS : Tracks 5 - 8

TRACK 5
Challenges in Drug Discovery and Development

Chairs: Lilly Xu, ChemPartner; Hua Lv, Roche

Implications of the New FDA Guidance for ADME Profiling
Stephen Fowler, Roche

The Application of in vitro Assays for in vivo DDI Prediction
Lilly Xu, Chempartner

Safety Assessments of Preclinical Candidates – Some Considerations from DMPK Perspectives
Hong Wan, Shanghai Hengrui

TRACK 6
Issues in Regulated Bioanalysis

Chairs: Naidong Weng, Janssen Research & Development; Tianyi Zhang, Frontage

Challenges of Immunogenicity Testing for Supporting Clinical Trials of Biotherapeutics
Weiping Shao, Regeneron

ADC PK Profiling Strategies on LC-MS Platforms: Top-Down, Bottom-Up, and Multiplexing
Song Zhao, Frontage

Advancement of High-throughput Bioanalysis to Support Research and Development of Oligonucleotide Therapeutics and Biomarkers
Laixin Wang, Denali Medpharma

TRACK 7
MS Imaging

Chair: Cornelis Hop, Genentech

MALDI-TOFMS Imaging for Environmental Toxicology
Chao Zhao, Hong Kong Baptist University

Imaging Mass Spectrometry: A Powerful Tool Enabling In Situ ADME Assessments
Cristine Quiason-Huynh, Genentech

Potential Usefulness of MS Imaging Technology with High Spatial Resolution in Pharmaceuticals
Miho Ayabe, Chugai

TRACK 8
Non-Cytochrome P450 Metabolism

Chairs: Jeff Zhang, Novartis; Kelly Dong, UP Pharma

Aldehyde Oxidase and its Involvement in the Metabolism of a cMet Inhibitor
Jeff Zhang, Novartis

An Investigation into the Prediction of in vivo Clearance for a Range of Flavin-Containing Monooxygenase Substrates
Yu Wang, Pharmaron

Induction of Aldehyde Oxidase by Nimesulide and its Regulation Mechanism
Lei Zhong, Shanghai Institute of Materia Medica

CPSA Social

Cocktails & Karaoke at CPSA

Whether you like to command the stage or cheer from the audience, it’s hard to have a forgettable time of karaoke.

Join colleagues and friends – old and new – to relax and unwind!

Request a song - click here!

Registration Open

Plenary Lecture

Poster Hall Open

Posters will be available all day today

Symposium Session

Drug Transporters

Chairs: Jasminder Sahi, Sanofi; Ikumi Tamai, Kanazawa University

Drug-Drug and Drug-Food Interaction on Transporters
Ikumi Tamai, Kanazawa University

Interactions Between Saponins and Hepatic Transporters
Chuan Li, Shanghai Institute of Materia Medica

Prediction of Brain-to-Blood Unbound Concentration Ratios in CNS Drug Discovery Employing in silico and in vitro Model Systems
Houfu Liu, GlaxoSmithKline

Contribution of Xenobiotic Transporters to Drug Disposition – Regulatory Case Studies
Jasminder Sahi, Sanofi

CPSA Shanghai Expo

Where Technology and Solutions Meet!

Lunch & Learn Workshops

WORKSHOP

Sponsored by New Objective

Translating Protein MS Assays and the Challenging Road Ahead
Dobrin Nedelkov, Isoformix