CPSA 2010
From Data to Biology:
Analytical Measurements to Drive Pharmaceutical R&D
October 18 - 21, 2010
Langhorne, PA
Poster Session
Tuesday, October 19
TP-01
Dried Matrix Spot Analysis - Analysis of Drugs from Tears and Other Translucent Fluids Using a Novel Color Indicating Technology
Chad D. Christianson, Casey J. Johnson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, Shane R. Needham
Alturas Analytics, Inc.
TP-02
Utility of Dried Blood Spot Sampling and Storage for Increased Stability of Photo-Sensitive Compounds
Chester L. Bowen1, Matthew D. Hemberger2, Jonathan R. Kehler1, and Christopher A. Evans1
1Platform Technology and Science, Drug Metabolism and Pharmacokinetics, Worldwide Bioanalysis and Systems Management, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406, USA; 2Platform Technology and Science, Pharmaceutical Development, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426
TP-03
On-line Microfluidic Extraction Enables Highly Efficient and Sensitive Direct Elution from Dried Blood Spots
Gary Valaskovic1; Christopher A. Evans2; Chester L Bowen2
1New Objective, Inc., Woburn, MA; 2GlaxoSmithKline, King Of Prussia, PA
TP-04
DBS Research at Abbott and Strategies to Implement in Bioanalysis
Katty Wan, Perry Fan, Raymond Xu, Olga Kavetskaia, Huaiqin Wu, Tawakol El-Shourbagy
Drug Analysis, Abbott, IL 60064, USA
TP-05
Novel Walk Away Automation for DBS sample extraction from 4-Spot Cards to LC-MS
Mike DeMayo, Peter Smith, Dave Holub
LEAP Technologies, Inc, PO Box 969, Carrboro, NC 27510
TP-06
The Simultaneous Analysis of Everolimus, Tacrolimus and Cyclosporin-A in Dried Blood Spots Using LC/MSMS
Lorraine Jacobs, Jos van den Elshout, Robert van der Wegen & Rudi Segers
Eurofins Medinet B.V., Bergschot 71, 4817 PA Breda, the Netherlands
TP-07
Simplification of off line analysis of microdialysis samples utilizing capped bar-coded Matrix inserts and an Eicom fraction collection setup
David Budac, Erin Shearman and Mark Hayward
Lundbeck Research USA, Paramas, NJ
TP-08
Improving Quality to Improve Throughput in Quantitative Neurotransmitter Analysis
David Budac and Mark Hayward
Lundbeck Research USA, Paramas, NJ
TP-09
Optimization of Sample Loading Capacity For Absolute Peptide Quantification by Nanobore LC-MS/MS
Chuck Witkowski1; Gary Valaskovic2; Jeremy L. Norris1; Mike S. Lee3
1Protein Discovery, Inc., Knoxville , TN; 2New Objective, Inc., Woburn, MA; 3Milestone Development Services, Newtown, PA
TP-10
A Novel Approach to Phospholipid Removal
Jessalynn Wheaton, Erin Chambers, Gary Mantha, John Martin
Waters Corporation, Milford, MA
TP-11
Addressing the Issues of Matrix Resolution and Measurement in Bioanalytical Assays
Paul D Rainville1, Marian Twohig1, Robert S Plumb1 and Ian Wilson2
1Waters Corporation, Milford, MA 01757, 2AstraZeneca, Macclesfield, UK
TP-12
Development of an Integrated Microscale Ceramic Separation Device to Address Limited Sample Volumes in Bioanalysis
Paul Rainville1; Michael Tomany2; James Murphy2; Norman Smith1; Joanne Mather2; Robert Plumb3
1King College, London, UK; 2Waters Corporation, Milford, MA; 3Imperial College, London, UNITED KINGDOM
TP-13
Component Elucidator the Software for Automated Analysis of High Resolution Accurate Mass LC-MS Datasets in Metabolomics
Serhiy Hnatyshyn1, Tom McClure2, Michael Reily1, Mark Sanders3
1Bristol-Myers Squibb Co., Rt. 206 & Provinceline Rd, Lawrenceville, NJ, 08543, USA; 2Thermo Fisher Scientific, San Jose, CA, USA; 3Thermo Fisher Scientific, Somerset, NJ, USA
TP-14
The Wonder of MS Finger Printing ’Äì A Story from the Development of GSK A
Cathy Chen, Ernest Schubert, Janine Rogers, Igor Goljer, Steve Castellino
Structure ID Group, Drug Metabolism and Pharmacokinetics, PTS, GlaxoSmithKline, King of Prussia, PA 19406, USA
TP-15
Cyanide-Trapped Reactive Metabolite Screening: QTrap vs QTOF
Joanna E. Barbara*, Seema Muranjan, Phyllis Yerino, Mark J. Horrigan, Paul C. Toren and Andrew Parkinson
XenoTech LLC, 16835 W. 116th St., Lenexa, KS 66219, USA
TP-16
On Line Analysis of Flowing Streams Using Microflow HPLC
Christopher J. Welch*, Xiaoyi Gong*, James Cuff, Sarah Dolman, Jason Nyrop, Fiona Lin, and Halena Rogers
Separation & Purification Center of Excellence, Department of Process Research, Merck & Co., Inc., Rahway, NJ, USA
TP-17
Use of Conventional LC Instrumentation in a Comparison Study of Semi-Porous and Porous Particles for Fast LC-MS-MS Analysis
Carmen T. Santasania and Wayne K. Way
Supelco/Sigma-Aldrich, 595 North Harrison Road, Bellefonte, PA 16823 USA
TP-18
Rapid High-Resolution LC-MS Analyses of Peptides and Tryptic Digests using New Fused-Core® Particle Columns
Stephanie Schuster1, Barry Boyes1,2, Darryl Johnson2, Joseph DeStefano1, Jack Kirkland1, and Ronald Orlando2
1Advanced Materials Technologies, Inc, Wilmington, DE; 2CCRC, University of Georgia, Athens, GA
TP-19
Nanobore RPHPLC: Determining The Role of Selectivity in Method Development
Amanda Berg, Carla Marshall-Waggett, Gary Valaskovic
New Objective, Inc., Woburn, MA
TP-20
Dried Blood Spot Analysis for Chiral Compounds: Determination of Warfarin Enantiomers in Human Blood Using HPLC and Tandem Mass Spectrometer
Hengchang Song, Yu Liu, Xinzhong Zhang, Yinghe Li, and Feng Li
Alliance Pharma, Inc.
